Publications


  1. Bernard-Gauthier, V, Bailey, JJ, Mossine, AV, Lindner, S, Vomacka, L, Aliaga, A et al.. A Kinome-Wide Selective Radiolabeled TrkB/C Inhibitor for in Vitro and in Vivo Neuroimaging: Synthesis, Preclinical Evaluation, and First-in-Human. J. Med. Chem. 2017; :. doi: 10.1021/acs.jmedchem.7b00396. PubMed PMID:28696690 .
  2. Lafaille-Magnan, ME, Poirier, J, Etienne, P, Tremblay-Mercier, J, Frenette, J, Rosa-Neto, P et al.. Odor identification as a biomarker of preclinical AD in older adults at risk. Neurology. 2017;89 (4):327-335. doi: 10.1212/WNL.0000000000004159. PubMed PMID:28659431 .
  3. Engelborghs, S, Niemantsverdriet, E, Struyfs, H, Blennow, K, Brouns, R, Comabella, M et al.. Consensus guidelines for lumbar puncture in patients with neurological diseases. Alzheimers Dement (Amst). 2017;8 :111-126. doi: 10.1016/j.dadm.2017.04.007. PubMed PMID:28603768 PubMed Central PMC5454085.
  4. Dadar, M, Pascoal, TA, Manitsirikul, S, Misquitta, K, Tartaglia, C, Brietner, J et al.. Validation of a Regression Technique for Segmentation of White Matter Hyperintensities in Alzheimer's Disease. IEEE Trans Med Imaging. 2017; :. doi: 10.1109/TMI.2017.2693978. PubMed PMID:28422655 .
  5. Ng, KP, Pascoal, TA, Mathotaarachchi, S, Chung, CO, Benedet, AL, Shin, M et al.. Neuropsychiatric symptoms predict hypometabolism in preclinical Alzheimer disease. Neurology. 2017;88 (19):1814-1821. doi: 10.1212/WNL.0000000000003916. PubMed PMID:28404803 PubMed Central PMC5419982.
  6. Chamoun, M, Huppé-Gourgues, F, Legault, I, Rosa-Neto, P, Dumbrava, D, Faubert, J et al.. Cholinergic Potentiation Improves Perceptual-Cognitive Training of Healthy Young Adults in Three Dimensional Multiple Object Tracking. Front Hum Neurosci. 2017;11 :128. doi: 10.3389/fnhum.2017.00128. PubMed PMID:28377707 PubMed Central PMC5359296.
  7. Ng, KP, Pascoal, TA, Mathotaarachchi, S, Therriault, J, Kang, MS, Shin, M et al.. Monoamine oxidase B inhibitor, selegiline, reduces (18)F-THK5351 uptake in the human brain. Alzheimers Res Ther. 2017;9 (1):25. doi: 10.1186/s13195-017-0253-y. PubMed PMID:28359327 PubMed Central PMC5374697.
  8. Zimmer, ER, Parent, MJ, Souza, DG, Leuzy, A, Lecrux, C, Kim, HI et al.. [(18)F]FDG PET signal is driven by astroglial glutamate transport. Nat. Neurosci. 2017;20 (3):393-395. doi: 10.1038/nn.4492. PubMed PMID:28135241 PubMed Central PMC5378483.
  9. Pascoal, TA, Mathotaarachchi, S, Shin, M, Benedet, AL, Mohades, S, Wang, S et al.. Synergistic interaction between amyloid and tau predicts the progression to dementia. Alzheimers Dement. 2017;13 (6):644-653. doi: 10.1016/j.jalz.2016.11.005. PubMed PMID:28024995 .
  10. Tam, A, Dansereau, C, Badhwar, A, Orban, P, Belleville, S, Chertkow, H et al.. A dataset of multiresolution functional brain parcellations in an elderly population with no or mild cognitive impairment. Data Brief. 2016;9 :1122-1129. doi: 10.1016/j.dib.2016.11.036. PubMed PMID:27924300 PubMed Central PMC5128734.
  11. Ba, M, Kong, M, Li, X, Ng, KP, Rosa-Neto, P, Gauthier, S et al.. Is ApoE ɛ 4 a good biomarker for amyloid pathology in late onset Alzheimer's disease?. Transl Neurodegener. 2016;5 :20. doi: 10.1186/s40035-016-0067-z. PubMed PMID:27891223 PubMed Central PMC5112745.
  12. Mechling, AE, Arefin, T, Lee, HL, Bienert, T, Reisert, M, Ben Hamida, S et al.. Deletion of the mu opioid receptor gene in mice reshapes the reward-aversion connectome. Proc. Natl. Acad. Sci. U.S.A. 2016;113 (41):11603-11608. doi: 10.1073/pnas.1601640113. PubMed PMID:27671662 PubMed Central PMC5068324.
  13. DuBois, JM, Rousset, OG, Guiot, MC, Hall, JA, Reader, AJ, Soucy, JP et al.. Metabotropic Glutamate Receptor Type 5 (mGluR5) Cortical Abnormalities in Focal Cortical Dysplasia Identified In Vivo With [11C]ABP688 Positron-Emission Tomography (PET) Imaging. Cereb. Cortex. 2016;26 (11):4170-4179. doi: 10.1093/cercor/bhw249. PubMed PMID:27578494 PubMed Central PMC5066831.
  14. Gibon, J, Kang, MS, Aliaga, A, Sharif, B, Rosa-Neto, P, Séguéla, P et al.. Towards the PET radiotracer for p75 neurotrophin receptor: [(11)C]LM11A-24 shows biological activity in vitro, but unfavorable ex vivo and in vivo profile. Bioorg. Med. Chem. 2016;24 (19):4759-65. doi: 10.1016/j.bmc.2016.08.020. PubMed PMID:27567078 .
  15. Turgeon, M, Oualkacha, K, Ciampi, A, Miftah, H, Dehghan, G, Zanke, BW et al.. Principal component of explained variance: An efficient and optimal data dimension reduction framework for association studies. Stat Methods Med Res. 2016; :. doi: 10.1177/0962280216660128. PubMed PMID:27460538 .
  16. Mathotaarachchi, S, Wang, S, Shin, M, Pascoal, TA, Benedet, AL, Kang, MS et al.. VoxelStats: A MATLAB Package for Multi-Modal Voxel-Wise Brain Image Analysis. Front Neuroinform. 2016;10 :20. doi: 10.3389/fninf.2016.00020. PubMed PMID:27378902 PubMed Central PMC4908129.
  17. Cho, J, Kwon, DH, Kim, RG, Song, H, Rosa-Neto, P, Lee, MC et al.. Remodeling of Neuronal Circuits After Reach Training in Chronic Capsular Stroke. Neurorehabil Neural Repair. 2016;30 (10):941-950. doi: 10.1177/1545968316650282. PubMed PMID:27198184 .
  18. Gauthier, S, Rosa-Neto, P, Kass, JS. Ethical Considerations for the Use of Next-Generation Alzheimer Drugs in Symptomatic and At-Risk Patients. Continuum (Minneap Minn). 2016;22 (2 Dementia):615-8. doi: 10.1212/CON.0000000000000306. PubMed PMID:27042911 PubMed Central PMC5390936.
  19. Pascoal, TA, Mathotaarachchi, S, Mohades, S, Benedet, AL, Chung, CO, Shin, M et al.. Amyloid-β and hyperphosphorylated tau synergy drives metabolic decline in preclinical Alzheimer's disease. Mol. Psychiatry. 2017;22 (2):306-311. doi: 10.1038/mp.2016.37. PubMed PMID:27021814 PubMed Central PMC5262471.
  20. Laforce, R, Rosa-Neto, P, Soucy, JP, Rabinovici, GD, Dubois, B, Gauthier, S et al.. Canadian Consensus Guidelines on Use of Amyloid Imaging in Canada: Update and Future Directions from the Specialized Task Force on Amyloid imaging in Canada. Can J Neurol Sci. 2016;43 (4):503-12. doi: 10.1017/cjn.2015.401. PubMed PMID:26916179 .
  21. Tam, A, Dansereau, C, Badhwar, A, Orban, P, Belleville, S, Chertkow, H et al.. Common Effects of Amnestic Mild Cognitive Impairment on Resting-State Connectivity Across Four Independent Studies. Front Aging Neurosci. 2015;7 :242. doi: 10.3389/fnagi.2015.00242. PubMed PMID:26733866 PubMed Central PMC4689788.
  22. Kim, RG, Cho, J, Ree, J, Kim, HS, Rosa-Neto, P, Kim, JM et al.. Sensory-parietal cortical stimulation improves motor recovery in severe capsular infarct. J. Cereb. Blood Flow Metab. 2016;36 (12):2211-2222. doi: 10.1177/0271678X15606136. PubMed PMID:26661148 PubMed Central PMC5363658.
  23. Benedet, AL, Labbe, A, Lemay, P, Zimmer, ER, Pascoal, TA, Leuzy, A et al.. Epistasis analysis links immune cascades and cerebral amyloidosis. J Neuroinflammation. 2015;12 :227. doi: 10.1186/s12974-015-0436-z. PubMed PMID:26626881 PubMed Central PMC4666175.
  24. Orban, P, Madjar, C, Savard, M, Dansereau, C, Tam, A, Das, S et al.. Test-retest resting-state fMRI in healthy elderly persons with a family history of Alzheimer's disease. Sci Data. 2015;2 :150043. doi: 10.1038/sdata.2015.43. PubMed PMID:26504522 PubMed Central PMC4603392.
  25. DuBois, JM, Rousset, OG, Rowley, J, Porras-Betancourt, M, Reader, AJ, Labbe, A et al.. Characterization of age/sex and the regional distribution of mGluR5 availability in the healthy human brain measured by high-resolution [(11)C]ABP688 PET. Eur. J. Nucl. Med. Mol. Imaging. 2016;43 (1):152-62. doi: 10.1007/s00259-015-3167-6. PubMed PMID:26290423 .
  26. Zimmer, ER, Parent, MJ, Leuzy, A, Aliaga, A, Aliaga, A, Moquin, L et al.. Imaging in vivo glutamate fluctuations with [(11)C]ABP688: a GLT-1 challenge with ceftriaxone. J. Cereb. Blood Flow Metab. 2015;35 (7):1169-74. doi: 10.1038/jcbfm.2015.35. PubMed PMID:25806702 PubMed Central PMC4640271.
  27. Leuzy, A, Zimmer, ER, Dubois, J, Pruessner, J, Cooperman, C, Soucy, JP et al.. In vivo characterization of metabotropic glutamate receptor type 5 abnormalities in behavioral variant FTD. Brain Struct Funct. 2016;221 (3):1387-402. doi: 10.1007/s00429-014-0978-3. PubMed PMID:25596865 .
  28. Zimmer, ER, Leuzy, A, Gauthier, S, Rosa-Neto, P. Developments in Tau PET Imaging. Can J Neurol Sci. 2014;41 (5):547-53. doi: 10.1017/cjn.2014.15. PubMed PMID:25424608 .
  29. Bernard-Gauthier, V, Aliaga, A, Aliaga, A, Boudjemeline, M, Hopewell, R, Kostikov, A et al.. Syntheses and evaluation of carbon-11- and fluorine-18-radiolabeled pan-tropomyosin receptor kinase (Trk) inhibitors: exploration of the 4-aza-2-oxindole scaffold as Trk PET imaging agents. ACS Chem Neurosci. 2015;6 (2):260-76. doi: 10.1021/cn500193f. PubMed PMID:25350780 .
  30. Cyr, M, Parent, MJ, Mechawar, N, Rosa-Neto, P, Soucy, JP, Clark, SD et al.. Deficit in sustained attention following selective cholinergic lesion of the pedunculopontine tegmental nucleus in rat, as measured with both post-mortem immunocytochemistry and in vivo PET imaging with [¹⁸F]fluoroethoxybenzovesamicol. Behav. Brain Res. 2015;278 :107-14. doi: 10.1016/j.bbr.2014.09.021. PubMed PMID:25257103 .
  31. Zimmer, ER, Parent, MJ, Cuello, AC, Gauthier, S, Rosa-Neto, P. MicroPET imaging and transgenic models: a blueprint for Alzheimer's disease clinical research. Trends Neurosci. 2014;37 (11):629-41. doi: 10.1016/j.tins.2014.07.002. PubMed PMID:25151336 .
  32. Zimmer, ER, Leuzy, A, Benedet, AL, Breitner, J, Gauthier, S, Rosa-Neto, P et al.. Tracking neuroinflammation in Alzheimer's disease: the role of positron emission tomography imaging. J Neuroinflammation. 2014;11 :120. doi: 10.1186/1742-2094-11-120. PubMed PMID:25005532 PubMed Central PMC4099095.
  33. Leuzy, A, Zimmer, ER, Heurling, K, Rosa-Neto, P, Gauthier, S. Use of amyloid PET across the spectrum of Alzheimer's disease: clinical utility and associated ethical issues. Amyloid. 2014;21 (3):143-8. doi: 10.3109/13506129.2014.926267. PubMed PMID:24919109 .
  34. Ongali, B, Nicolakakis, N, Tong, XK, Aboulkassim, T, Papadopoulos, P, Rosa-Neto, P et al.. Angiotensin II type 1 receptor blocker losartan prevents and rescues cerebrovascular, neuropathological and cognitive deficits in an Alzheimer's disease model. Neurobiol. Dis. 2014;68 :126-36. doi: 10.1016/j.nbd.2014.04.018. PubMed PMID:24807206 .
  35. Milella, MS, Marengo, L, Larcher, K, Fotros, A, Dagher, A, Rosa-Neto, P et al.. Limbic system mGluR5 availability in cocaine dependent subjects: a high-resolution PET [(11)C]ABP688 study. Neuroimage. 2014;98 :195-202. doi: 10.1016/j.neuroimage.2014.04.061. PubMed PMID:24795154 .
  36. Zimmer, ER, Leuzy, A, Bhat, V, Gauthier, S, Rosa-Neto, P. In vivo tracking of tau pathology using positron emission tomography (PET) molecular imaging in small animals. Transl Neurodegener. 2014;3 (1):6. doi: 10.1186/2047-9158-3-6. PubMed PMID:24628994 PubMed Central PMC3995516.
  37. Wu, L, Soder, RB, Schoemaker, D, Carbonnell, F, Sziklas, V, Rowley, J et al.. Resting state executive control network adaptations in amnestic mild cognitive impairment. J. Alzheimers Dis. 2014;40 (4):993-1004. doi: 10.3233/JAD-131574. PubMed PMID:24583406 .
  38. Rosa-Neto, P, Hsiung, GY, Masellis, M, CCDTD4 participants. Fluid biomarkers for diagnosing dementia: rationale and the Canadian Consensus on Diagnosis and Treatment of Dementia recommendations for Canadian physicians. Alzheimers Res Ther. 2013;5 (Suppl 1):S8. doi: 10.1186/alzrt223. PubMed PMID:24565514 PubMed Central PMC3980280.
  39. Burhan, AM, Bartha, R, Bocti, C, Borrie, M, Laforce, R, Rosa-Neto, P et al.. Role of emerging neuroimaging modalities in patients with cognitive impairment: a review from the Canadian Consensus Conference on the Diagnosis and Treatment of Dementia 2012. Alzheimers Res Ther. 2013;5 (Suppl 1):S4. doi: 10.1186/alzrt200. PubMed PMID:24565285 PubMed Central PMC3981649.
  40. Soucy, JP, Bartha, R, Bocti, C, Borrie, M, Burhan, AM, Laforce, R et al.. Clinical applications of neuroimaging in patients with Alzheimer's disease: a review from the Fourth Canadian Consensus Conference on the Diagnosis and Treatment of Dementia 2012. Alzheimers Res Ther. 2013;5 (Suppl 1):S3. doi: 10.1186/alzrt199. PubMed PMID:24565260 PubMed Central PMC3980588.
  41. Leuzy, A, Zimmer, ER, Bhat, V, Rosa-Neto, P, Gauthier, S. Imaging biomarkers for amyloid: a new generation of probes and what lies ahead. Int Psychogeriatr. 2014;26 (5):703-7. doi: 10.1017/S1041610214000118. PubMed PMID:24524685 .
  42. Parent, MJ, Bedard, MA, Aliaga, A, Minuzzi, L, Mechawar, N, Soucy, JP et al.. Cholinergic Depletion in Alzheimer's Disease Shown by [ (18) F]FEOBV Autoradiography. Int J Mol Imaging. 2013;2013 :205045. doi: 10.1155/2013/205045. PubMed PMID:24324884 PubMed Central PMC3844185.
  43. Cyr, M, Parent, MJ, Mechawar, N, Rosa-Neto, P, Soucy, JP, Aliaga, A et al.. PET imaging with [¹⁸F]fluoroethoxybenzovesamicol ([¹⁸F]FEOBV) following selective lesion of cholinergic pedunculopontine tegmental neurons in rat. Nucl. Med. Biol. 2014;41 (1):96-101. doi: 10.1016/j.nucmedbio.2013.10.004. PubMed PMID:24267056 .
  44. Bernard-Gauthier, V, Boudjemeline, M, Rosa-Neto, P, Thiel, A, Schirrmacher, R. Towards tropomyosin-related kinase B (TrkB) receptor ligands for brain imaging with PET: radiosynthesis and evaluation of 2-(4-[(18)F]fluorophenyl)-7,8-dihydroxy-4H-chromen-4-one and 2-(4-([N-methyl-(11)C]-dimethylamino)phenyl)-7,8-dihydroxy-4H-chromen-4-one. Bioorg. Med. Chem. 2013;21 (24):7816-29. doi: 10.1016/j.bmc.2013.10.012. PubMed PMID:24183588 .
  45. Gauthier, S, Rosa-Neto, P. Dementia: Disclosure of results to participants in dementia research. Nat Rev Neurol. 2013;9 (11):608-9. doi: 10.1038/nrneurol.2013.213. PubMed PMID:24145370 .
  46. Parent, MJ, Cyr, M, Aliaga, A, Kostikov, A, Schirrmacher, E, Soucy, JP et al.. Concordance between in vivo and postmortem measurements of cholinergic denervation in rats using PET with [18F]FEOBV and choline acetyltransferase immunochemistry. EJNMMI Res. 2013;3 (1):70. doi: 10.1186/2191-219X-3-70. PubMed PMID:24103360 PubMed Central PMC3852759.
  47. Rowley, J, Fonov, V, Wu, O, Eskildsen, SF, Schoemaker, D, Wu, L et al.. White matter abnormalities and structural hippocampal disconnections in amnestic mild cognitive impairment and Alzheimer's disease. PLoS ONE. 2013;8 (9):e74776. doi: 10.1371/journal.pone.0074776. PubMed PMID:24086371 PubMed Central PMC3785512.
  48. Gauthier, S, Leuzy, A, Rosa-Neto, P. How can we improve transfer of outcomes from randomized clinical trials to clinical practice with disease-modifying drugs in Alzheimer's disease?. Neurodegener Dis. 2014;13 (2-3):197-9. doi: 10.1159/000353748. PubMed PMID:23942173 .
  49. Papadopoulos, P, Rosa-Neto, P, Rochford, J, Hamel, E. Pioglitazone improves reversal learning and exerts mixed cerebrovascular effects in a mouse model of Alzheimer's disease with combined amyloid-β and cerebrovascular pathology. PLoS ONE. 2013;8 (7):e68612. doi: 10.1371/journal.pone.0068612. PubMed PMID:23874687 PubMed Central PMC3715495.
  50. Kandratavicius, L, Rosa-Neto, P, Monteiro, MR, Guiot, MC, Assirati, JA Jr, Carlotti, CG Jr et al.. Distinct increased metabotropic glutamate receptor type 5 (mGluR5) in temporal lobe epilepsy with and without hippocampal sclerosis. Hippocampus. 2013;23 (12):1212-30. doi: 10.1002/hipo.22160. PubMed PMID:23804486 PubMed Central PMC4165311.
  51. Gauthier, S, Leuzy, A, Racine, E, Rosa-Neto, P. Diagnosis and management of Alzheimer's disease: past, present and future ethical issues. Prog. Neurobiol. 2013;110 :102-13. doi: 10.1016/j.pneurobio.2013.01.003. PubMed PMID:23578568 .
  52. Gauthier, S, Patterson, C, Chertkow, H, Gordon, M, Herrmann, N, Rockwood, K et al.. Recommendations of the 4th Canadian Consensus Conference on the Diagnosis and Treatment of Dementia (CCCDTD4). Can Geriatr J. 2012;15 (4):120-6. doi: 10.5770/cgj.15.49. PubMed PMID:23259025 PubMed Central PMC3516356.
  53. Gauthier, S, Patterson, C, Chertkow, H, Gordon, M, Herrmann, N, Rockwood, K et al.. 4th Canadian Consensus Conference on the Diagnosis and Treatment of Dementia. Can J Neurol Sci. 2012;39 (6 Suppl 5):S1-8. . PubMed PMID:23073396 .
  54. Gauthier, S, Wu, L, Rosa-Neto, P, Jia, J. Prevention strategies for Alzheimer's disease. Transl Neurodegener. 2012;1 (1):13. doi: 10.1186/2047-9158-1-13. PubMed PMID:23210473 PubMed Central PMC3514088.
  55. Wu, L, Rowley, J, Mohades, S, Leuzy, A, Dauar, MT, Shin, M et al.. Dissociation between brain amyloid deposition and metabolism in early mild cognitive impairment. PLoS ONE. 2012;7 (10):e47905. doi: 10.1371/journal.pone.0047905. PubMed PMID:23112868 PubMed Central PMC3480449.
  56. Wu, L, Rosa-Neto, P, Hsiung, GY, Sadovnick, AD, Masellis, M, Black, SE et al.. Early-onset familial Alzheimer's disease (EOFAD). Can J Neurol Sci. 2012;39 (4):436-45. . PubMed PMID:22728850 .
  57. Parent, M, Bedard, MA, Aliaga, A, Soucy, JP, Landry St-Pierre, E, Cyr, M et al.. PET imaging of cholinergic deficits in rats using [18F]fluoroethoxybenzovesamicol ([18F]FEOBV). Neuroimage. 2012;62 (1):555-61. doi: 10.1016/j.neuroimage.2012.04.032. PubMed PMID:22555071 .
  58. Tong, XK, Lecrux, C, Rosa-Neto, P, Hamel, E. Age-dependent rescue by simvastatin of Alzheimer's disease cerebrovascular and memory deficits. J. Neurosci. 2012;32 (14):4705-15. doi: 10.1523/JNEUROSCI.0169-12.2012. PubMed PMID:22492027 .
  59. Zhao, L, Boucher, M, Rosa-Neto, P, Evans, AC. Impact of scale space search on age- and gender-related changes in MRI-based cortical morphometry. Hum Brain Mapp. 2013;34 (9):2113-28. doi: 10.1002/hbm.22050. PubMed PMID:22422546 .
  60. Kovačević, T, Skelin, I, Minuzzi, L, Rosa-Neto, P, Diksic, M. Reduced metabotropic glutamate receptor 5 in the Flinders Sensitive Line of rats, an animal model of depression: an autoradiographic study. Brain Res. Bull. 2012;87 (4-5):406-12. doi: 10.1016/j.brainresbull.2012.01.010. PubMed PMID:22310150 PubMed Central PMC3641045.
  61. Elmenhorst, D, Aliaga, A, Bauer, A, Rosa-Neto, P. Test-retest stability of cerebral mGluR₅ quantification using [¹¹C]ABP688 and positron emission tomography in rats. Synapse. 2012;66 (6):552-60. doi: 10.1002/syn.21542. PubMed PMID:22290765 .
  62. Wu, L, Rosa-Neto, P, Gauthier, S. Use of biomarkers in clinical trials of Alzheimer disease: from concept to application. Mol Diagn Ther. 2011;15 (6):313-25. doi: 10.2165/11595090-000000000-00000. PubMed PMID:22188635 .
  63. Berney, A, Leyton, M, Gravel, P, Sibon, I, Sookman, D, Rosa Neto, P et al.. Brain regional α-[11C]methyl-L-tryptophan trapping in medication-free patients with obsessive-compulsive disorder. Arch. Gen. Psychiatry. 2011;68 (7):732-41. doi: 10.1001/archgenpsychiatry.2011.16. PubMed PMID:21383250 PubMed Central PMC3677917.
  64. Chen, ZJ, He, Y, Rosa-Neto, P, Gong, G, Evans, AC. Age-related alterations in the modular organization of structural cortical network by using cortical thickness from MRI. Neuroimage. 2011;56 (1):235-45. doi: 10.1016/j.neuroimage.2011.01.010. PubMed PMID:21238595 .
  65. Oishi, K, Huang, H, Yoshioka, T, Ying, SH, Zee, DS, Zilles, K et al.. Superficially located white matter structures commonly seen in the human and the macaque brain with diffusion tensor imaging. Brain Connect. 2011;1 (1):37-47. doi: 10.1089/brain.2011.0005. PubMed PMID:22432953 PubMed Central PMC3569096.
  66. Ongali, B, Nicolakakis, N, Lecrux, C, Aboulkassim, T, Rosa-Neto, P, Papadopoulos, P et al.. Transgenic mice overexpressing APP and transforming growth factor-beta1 feature cognitive and vascular hallmarks of Alzheimer's disease. Am. J. Pathol. 2010;177 (6):3071-80. doi: 10.2353/ajpath.2010.100339. PubMed PMID:21088218 PubMed Central PMC2993264.
  67. Bertomeu, T, Zvereff, V, Ibrahim, A, Zehntner, SP, Aliaga, A, Rosa-Neto, P et al.. TLN-4601 peripheral benzodiazepine receptor (PBR/TSPO) binding properties do not mediate apoptosis but confer tumor-specific accumulation. Biochem. Pharmacol. 2010;80 (10):1572-9. doi: 10.1016/j.bcp.2010.07.018. PubMed PMID:20655882 .
  68. Verhaeghe, J, Gravel, P, Mio, R, Fukasawa, R, Rosa-Neto, P, Soucy, JP et al.. Motion compensation for fully 4D PET reconstruction using PET superset data. Phys Med Biol. 2010;55 (14):4063-82. doi: 10.1088/0031-9155/55/14/008. PubMed PMID:20601774 .
  69. Nicolakakis, N, Aboulkassim, T, Aliaga, A, Tong, XK, Rosa-Neto, P, Hamel, E et al.. Intact memory in TGF-β1 transgenic mice featuring chronic cerebrovascular deficit: recovery with pioglitazone. J. Cereb. Blood Flow Metab. 2011;31 (1):200-11. doi: 10.1038/jcbfm.2010.78. PubMed PMID:20571524 PubMed Central PMC3049484.
  70. Zhang, Y, Zhang, J, Oishi, K, Faria, AV, Jiang, H, Li, X et al.. Atlas-guided tract reconstruction for automated and comprehensive examination of the white matter anatomy. Neuroimage. 2010;52 (4):1289-301. doi: 10.1016/j.neuroimage.2010.05.049. PubMed PMID:20570617 PubMed Central PMC2910162.
  71. Elmenhorst, D, Minuzzi, L, Aliaga, A, Rowley, J, Massarweh, G, Diksic, M et al.. In vivo and in vitro validation of reference tissue models for the mGluR(5) ligand [(11)C]ABP688. J. Cereb. Blood Flow Metab. 2010;30 (8):1538-49. doi: 10.1038/jcbfm.2010.65. PubMed PMID:20531460 PubMed Central PMC2949244.
  72. Bellec, P, Rosa-Neto, P, Lyttelton, OC, Benali, H, Evans, AC. Multi-level bootstrap analysis of stable clusters in resting-state fMRI. Neuroimage. 2010;51 (3):1126-39. doi: 10.1016/j.neuroimage.2010.02.082. PubMed PMID:20226257 .
  73. Gong, G, Rosa-Neto, P, Carbonell, F, Chen, ZJ, He, Y, Evans, AC et al.. Age- and gender-related differences in the cortical anatomical network. J. Neurosci. 2009;29 (50):15684-93. doi: 10.1523/JNEUROSCI.2308-09.2009. PubMed PMID:20016083 PubMed Central PMC2831804.
  74. la Fougère, C, Böning, G, Bartmann, H, Wängler, B, Nowak, S, Just, T et al.. Uptake and binding of the serotonin 5-HT1A antagonist [18F]-MPPF in brain of rats: effects of the novel P-glycoprotein inhibitor tariquidar. Neuroimage. 2010;49 (2):1406-15. doi: 10.1016/j.neuroimage.2009.09.048. PubMed PMID:19796699 .
  75. Massarweh, G, Kovacevic, M, Rosa-Neto, P, Evans, AC, Diksic, M, Schirrmacher, R et al.. Time-efficient and convenient synthesis of [(18)F]altanserin for human PET imaging by a new work-up procedure. Appl Radiat Isot. 2009;67 (11):2040-3. doi: 10.1016/j.apradiso.2009.07.020. PubMed PMID:19692252 .
  76. Chakravarty, MM, Broadbent, S, Rosa-Neto, P, Lambert, CM, Collins, DL. Design, construction, and validation of an MRI-compatible vibrotactile stimulator intended for clinical use. J. Neurosci. Methods. 2009;184 (1):129-35. doi: 10.1016/j.jneumeth.2009.07.018. PubMed PMID:19631690 .
  77. Rosa-Neto, P, Wängler, B, Iovkova, L, Boening, G, Reader, A, Jurkschat, K et al.. [18F]SiFA-isothiocyanate: a new highly effective radioactive labeling agent for lysine-containing proteins. Chembiochem. 2009;10 (8):1321-4. doi: 10.1002/cbic.200900132. PubMed PMID:19422010 .
  78. Oishi, K, Faria, A, Jiang, H, Li, X, Akhter, K, Zhang, J et al.. Atlas-based whole brain white matter analysis using large deformation diffeomorphic metric mapping: application to normal elderly and Alzheimer's disease participants. Neuroimage. 2009;46 (2):486-99. . PubMed PMID:19385016 PubMed Central PMC2885858.
  79. Nicolakakis, N, Aboulkassim, T, Ongali, B, Lecrux, C, Fernandes, P, Rosa-Neto, P et al.. Complete rescue of cerebrovascular function in aged Alzheimer's disease transgenic mice by antioxidants and pioglitazone, a peroxisome proliferator-activated receptor gamma agonist. J. Neurosci. 2008;28 (37):9287-96. doi: 10.1523/JNEUROSCI.3348-08.2008. PubMed PMID:18784309 .
  80. Aznavour, N, Benkelfat, C, Gravel, P, Aliaga, A, Rosa-Neto, P, Bedell, B et al.. MicroPET imaging of 5-HT 1A receptors in rat brain: a test-retest [18F]MPPF study. Eur. J. Nucl. Med. Mol. Imaging. 2009;36 (1):53-62. doi: 10.1007/s00259-008-0891-1. PubMed PMID:18704404 .
  81. Oishi, K, Zilles, K, Amunts, K, Faria, A, Jiang, H, Li, X et al.. Human brain white matter atlas: identification and assignment of common anatomical structures in superficial white matter. Neuroimage. 2008;43 (3):447-57. doi: 10.1016/j.neuroimage.2008.07.009. PubMed PMID:18692144 PubMed Central PMC2586008.
  82. Frey, BN, Rosa-Neto, P, Lubarsky, S, Diksic, M. Correlation between serotonin synthesis and 5-HT1A receptor binding in the living human brain: a combined alpha-[11C]MT and [18F]MPPF positron emission tomography study. Neuroimage. 2008;42 (2):850-7. doi: 10.1016/j.neuroimage.2008.05.009. PubMed PMID:18583156 .
  83. Chakravarty, MM, Rosa-Neto, P, Broadbent, S, Evans, AC, Collins, DL. Robust S1, S2, and thalamic activations in individual subjects with vibrotactile stimulation at 1.5 and 3.0 T. Hum Brain Mapp. 2009;30 (4):1328-37. doi: 10.1002/hbm.20598. PubMed PMID:18537113 .
  84. Chen, ZJ, He, Y, Rosa-Neto, P, Germann, J, Evans, AC. Revealing modular architecture of human brain structural networks by using cortical thickness from MRI. Cereb. Cortex. 2008;18 (10):2374-81. doi: 10.1093/cercor/bhn003. PubMed PMID:18267952 PubMed Central PMC2733312.
  85. Rosa-Neto, P, Benkelfat, C, Sakai, Y, Leyton, M, Morais, JA, Diksic, M et al.. Brain regional alpha-[11C]methyl-L-tryptophan trapping, used as an index of 5-HT synthesis, in healthy adults: absence of an age effect. Eur. J. Nucl. Med. Mol. Imaging. 2007;34 (8):1254-64. doi: 10.1007/s00259-007-0365-x. PubMed PMID:17318550 .
  86. Pedersen, K, Simonsen, M, Østergaard, SD, Munk, OL, Rosa-Neto, P, Olsen, AK et al.. Mapping the amphetamine-evoked changes in [11C]raclopride binding in living rat using small animal PET: modulation by MAO-inhibition. Neuroimage. 2007;35 (1):38-46. doi: 10.1016/j.neuroimage.2006.11.038. PubMed PMID:17223363 .
  87. Doudet, DJ, Rosa-Neto, P, Munk, OL, Ruth, TJ, Jivan, S, Cumming, P et al.. Effect of age on markers for monoaminergic neurons of normal and MPTP-lesioned rhesus monkeys: a multi-tracer PET study. Neuroimage. 2006;30 (1):26-35. doi: 10.1016/j.neuroimage.2005.09.044. PubMed PMID:16378735 .
  88. Leyton, M, Paquette, V, Gravel, P, Rosa-Neto, P, Weston, F, Diksic, M et al.. alpha-[11C]Methyl-L-tryptophan trapping in the orbital and ventral medial prefrontal cortex of suicide attempters. Eur Neuropsychopharmacol. 2006;16 (3):220-3. doi: 10.1016/j.euroneuro.2005.09.006. PubMed PMID:16269239 .
  89. Rosa-Neto, P, Diksic, M, Leyton, M, Mzengeza, S, Benkelfat, C. Stability of alpha-[11C]methyl-L-tryptophan brain trapping in healthy male volunteers. Eur. J. Nucl. Med. Mol. Imaging. 2005;32 (10):1199-204. doi: 10.1007/s00259-005-1829-5. PubMed PMID:15948006 .
  90. Rosa-Neto, P, Lou, HC, Cumming, P, Pryds, O, Karrebaek, H, Lunding, J et al.. Methylphenidate-evoked changes in striatal dopamine correlate with inattention and impulsivity in adolescents with attention deficit hyperactivity disorder. Neuroimage. 2005;25 (3):868-76. doi: 10.1016/j.neuroimage.2004.11.031. PubMed PMID:15808987 .
  91. Gjedde, A, Wong, DF, Rosa-Neto, P, Cumming, P. Mapping neuroreceptors at work: on the definition and interpretation of binding potentials after 20 years of progress. Int. Rev. Neurobiol. 2005;63 :1-20. doi: 10.1016/S0074-7742(05)63001-2. PubMed PMID:15797463 .
  92. Rosa-Neto, P, Gjedde, A, Olsen, AK, Jensen, SB, Munk, OL, Watanabe, H et al.. MDMA-evoked changes in [11C]raclopride and [11C]NMSP binding in living pig brain. Synapse. 2004;53 (4):222-33. doi: 10.1002/syn.20053. PubMed PMID:15266554 .
  93. Rosa-Neto, P, Olsen, AK, Gjedde, A, Watanabe, H, Cumming, P. MDMA-evoked changes in cerebral blood flow in living porcine brain: correlation with hyperthermia. Synapse. 2004;53 (4):214-21. doi: 10.1002/syn.20052. PubMed PMID:15266553 .
  94. Rosa-Neto, P, Doudet, DJ, Cumming, P. Gradients of dopamine D1- and D2/3-binding sites in the basal ganglia of pig and monkey measured by PET. Neuroimage. 2004;22 (3):1076-83. doi: 10.1016/j.neuroimage.2004.03.004. PubMed PMID:15219579 .
  95. Rosa-Neto, P, Diksic, M, Okazawa, H, Leyton, M, Ghadirian, N, Mzengeza, S et al.. Measurement of brain regional alpha-[11C]methyl-L-tryptophan trapping as a measure of serotonin synthesis in medication-free patients with major depression. Arch. Gen. Psychiatry. 2004;61 (6):556-63. doi: 10.1001/archpsyc.61.6.556. PubMed PMID:15184235 .
  96. Cumming, P, Rosa-Neto, P, Watanabe, H, Smith, D, Bender, D, Clarke, PB et al.. Effects of acute nicotine on hemodynamics and binding of [11C]raclopride to dopamine D2,3 receptors in pig brain. Neuroimage. 2003;19 (3):1127-36. . PubMed PMID:12880838 .
  97. Rosa Neto, P, Lou, H, Cumming, P, Pryds, O, Gjedde, A. Methylphenidate-evoked potentiation of extracellular dopamine in the brain of adolescents with premature birth: correlation with attentional deficit. Ann. N. Y. Acad. Sci. 2002;965 :434-9. . PubMed PMID:12105118 .
  98. Bernasconi, A, Martinez, V, Rosa-Neto, P, D'Agostino, D, Bernasconi, N, Berkovic, S et al.. Surgical resection for intractable epilepsy in "double cortex" syndrome yields inadequate results. Epilepsia. 2001;42 (9):1124-9. . PubMed PMID:11580758 .
  99. Lopes-Cendes, I, Teive, HG, Calcagnotto, ME, Da Costa, JC, Cardoso, F, Viana, E et al.. Frequency of the different mutations causing spinocerebellar ataxia (SCA1, SCA2, MJD/SCA3 and DRPLA) in a large group of Brazilian patients. Arq Neuropsiquiatr. 1997;55 (3B):519-29. . PubMed PMID:9629399 .
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